| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Optimization of calcitonin(sCT)-sodium tripolyphosphate(STPP) nano ionic complex and its in vitro LLC-PK1 cell permeation, cAMP release in T47D breast cancer cell line and in vivo PK, PD study |
| 초록 |
sCT-STPP ionic complex was fabricated based on our previous protocols (J controlled Rel 143 (2010) 251–257) and characterized with TEM, DSC and FT-IR. In vitro release test, cAMP release study using T47D breast cancer cell line, LLC-PK1 cell permeation study, in vivo pharmacokinetic and pharmacodynamic studies were performed. The particle size was around 50-100 nm and the complexation efficiency was c.a. 98~99%. sCT was released for 2-3 weeks in vitro. sCT permeation of 1:50 formulation through LLC-PK1 cell was superior than other formulations. The in vivo study has shown that sCT/STPP ionic complexes exhibited superior hypocalcemic effects compared to free sCT. |
| 저자 |
오동호1, 전상옥1, 서조은2, 이상길2
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| 소속 |
1인제대, 2계명대 |
| 키워드 |
calcitonin; ionic complex; cell permeation; in vitro release
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| E-Mail |
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