| 초록 |
Bone healing is one of the importance phenomena in clinical fields including oral, maxillofacial, orthopedic, and plastic surgeries. In general, a major obstacle in bone healing involves the rapid appearance of connective tissue. The presence of connective tissue at the bone defect site prevents osteogenesis, resulting in the incomplete bone formation having low mechanical strength and cartilage-like tissue. To overcome this problem, guide bone regeneration (GBR) membranes made of collagen, expanded polytetrafluoro ethylene (e-PTFE), polylactic acid (PLA), polyglycolic acid (PGA), and poly(DL-lactic-co-glycolic acid) (PLGA) have been used to prevent connective tissue infiltration into the bone defect. However, their fast absorption or non-absorption, brittleness leading to surrounding tissue defect, and permeability which should prevent connective tissue invasion but allow oxygen and nutrient supply are still remained as limitations. In this study, we prepared GBR membranes with the porosity of submicron pore sizes (to prevent connective tissue infiltration), hydrophilicity (for effective oxygen and nutrient permeation), and flexibility (to prevent surrounding tissue damage) using PLGA and Pluronic F127 (with different F127 ratio) by a solvent casting & immersion precipitation method designed by our laboratory. The mechanical strength, hydrophilicity, morphology, and model nutrient permeability of the prepared GBR membranes were investigated. The dimensional stability and mechanical property changes of the GBR membranes were also evaluated according to the different sterilization conditions. |
