| 학회 | 한국공업화학회 |
| 학술대회 | 2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 | 20권 1호 |
| 발표분야 | 우수논문(구두)_석사과정 |
| 제목 | Tumor Therapeutic Effect of Thermo-Responsive Melanin Hydrogels as a Photothermal Therapeutic Agent |
| 초록 | In this study, we suggest thermo-responsive melanin hydrogels as a photothermal therapeutic agent for cancer treatment. Thermo-responsive polymer solution containing melanin (MEL sol.) formed a hydrogel at body temperature and showed excellent photothermal effects when exposed to near infrared (NIR) 808 nm irradiation. MEL sol. with various concentration was incubated with CT 26 cells. The majority of cells were destroyed after the laser exposure at 1.5 W/cm2 for 3 min. Following intratumoral injection of MEL sol. into tumors of xenograft-bearing mice, near infrared (NIR) 808 nm laser was irradiated at 1.5 W/cm2 for 3 min to the tumor tissue. After laser irradiation, MEL sol. induced photothermal tumor ablation and the tumor tissues were successfully destroyed. As a result, we anticipated that thermo-responsive melanin solution could become an attractive PTT agent for cancer therapy. Acknowledgements: Basic Science Research Program (NRF-2015R1C1A1A02036746). |
| 저자 | 김미리, 김민아, 정호용, 윤순도, 이창문 |
| 소속 | 전남대 |
| 키워드 | Melanin; Photothermal Therapy; Thermo-Responsive Polymer |
