| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Photothermal Effects of Liposomes Containing Melanin on NIR Laser Irradiation |
| 초록 |
Melanin is an effective absorber of light to near infrared (NIR) regions. It is, however, insoluble in water and so the ranges to be used are limited. Here, we prepared the melanin-loaded liposomes (melasomes) for biomedical applications and evaluated photothermal effects in vivo and in vitro. The melasomes were spherical vesicles of 160 nm in diameter. After irradiation from 808 nm NIR laser at 1.5 W/cm2, the melasomes showed a good photothermal conversion efficiency in vivo and in vitro. The temperature of the melasome solution increased to 48.6 ℃ within 7 min under the same irradiation condition. At 4 h post-injection of the melasome solution through the tail vein, the temperature of the tumors of mice bearing CT26 reached 50.8 ℃ within 3 min under the irradiation. The tumors treated with laser irradiation showed slower growth significantly. We anticipate that melasome solution could become an attractive photothermal therapeutic agent for cancer therapy. |
| 저자 |
김미리1, 김민아1, 정호용1, 윤순도1, 김동운2, 이창문1
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| 소속 |
1전남대, 2광양보건대 |
| 키워드 |
Melanin; Liposome; Photothermal cancer therapy; Photothermal therapeutic agent
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| E-Mail |
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