| 초록 |
In recent years, several techniques have been used to manufacture porous polymeric scaffolds having 3-dimensional structure. But these scaffolds usually have limitations for some applications because of their hydrophobicity and stiffness. These properties led to be inefficient in cell seeding and growth as well as handling difficulties. To overcome these problems, we fabricated natural polymer (sodium alginate)/synthetic polymer (polyvinyl alcohol (PVA)) hybrid scaffolds with improved hydrophilicity, flexibility and tissue compatibility. Alginate/PVA hybrid scaffolds with different alginate and PVA compositions were fabricated by a modified freeze-drying method and the following crosslinking of sodium alginate (using 2 % CaCl2) and PVA (using 5 % glutaraldehyde) in the hybrid scaffolds. It was observed that PVA influences on the pore size of scaffolds. The pore size was decreased with the increasing PVA composition in the scaffolds, whereas total porosity of the scaffolds were not changed. Alginate/PVA hybrid scaffolds having a different alginate and PVA compositions were also characterized by the measurements of biaxial mechanical properties, water absorption, dimensional stability in cell culture medium, and cell compatibility.
|
