| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.86 |
| 발표분야 | 신규고분자 합성 |
| 제목 | Layer-by-layer (LbL) deposition for the creation of functional polymeric surface coatings |
| 초록 | Controlling the interactions of proteins and cells with surfaces is critically important in manipulating and studying cellular responses such as adhesion, growth rate, motility and differentiation as well as surface mediated apoptosis that may help to prevent failure of implanted medical devices. Previous studies in creating cell adhesion resistant (bio-inert) coating have been focused on only a few materials, yet the practical methodology to create conformal coating over large-area has not been achieved. A promising alternative for assembling soft materials for functional surface coatings is layer-by-layer assembly. Layer-by-layer deposition (LbL) is a versatile technique whereby ultrathin films are assembled from the repetitive, sequential adsorption of oppositely charged polyelectrolytes from dilute aqueous solution.1 It allows nano-scale control over the thickness, composition, and molecular structure of the deposited film.2 Recently, we developed a system to deposit thin films using hydrogen bonding interactions between polymers.3-5 The as-assembled films are sensitive to pH change: they dissolve in high pH solution due to disruption of H-bonding. The films can be selectively stabilized to form micropatterns using inkjet or photo-lithographic methods.3 In particular, they are stable in physiological condition, pH 7.4 with a moderate ionic strength. The stabilized multilayer films exhibit superb resistance to cell adhesion (fibroblasts, hepatocytes, etc) with long-term durability.4 The surface of the multilayer film can be functionalized further with specific functional groups such as a cell adhesion peptide ligand.5 The excellent micropatternability of the films and the tunability of their affinity to cells enabled us to study cellular interactions with surfaces. More recently, this H-bonded multilayer was deposited on small colloids (micro- nano-sized) without flocculation, which shows a great potential in selective drug delivery.6 In addition to cellular interaction control, anti-bacterial coating will be also discussed. 참고문헌 1. G. Decher, J. D. Hong, Makromol. Chem. Macromol. Symp. 16, 321 (1991); G. Decher, Science, 277, 1232 (1997) 2. S. Shiratori, M. F. Rubner, Macromlecules,33, 4213 (2000) 3. S.Y. Yang, M.F. Rubner, J. Am. Chem. Soc., 124, 2100 (2002) 4. S. Y. Yang, J. Mendelshon, M.F. Rubner, Biomacromolecules, 4 (4), 987 (2003) 5. M.C. Berg, S. Y. Yang, P.T. Hammond, M.F. Rubner, Langmuir, 20, 1362 (2004) 6. S. Y. Yang, D. Lee, R. E. Cohen, M. F. Rubner, Langmuir, 20, 5978 (2004) |
| 저자 | 양성윤 |
| 소속 | 생명 공학 (연) |
| 키워드 | polyelectrolyte; multilayer; layer-by-layer; biofunctional coating |
