| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
In vitro Release Behavior of Zaltoprofen added Cosurfactant in PLGA Microspheres: Preparation and Characterization |
| 초록 |
Zaltoprofen is known to have powerful inhibitory effects on acute, subacute and chronic inflammation. We developed poly(lactide-co-glycolide) (PLGA) microspheres loaded with zaltoprofen for sustained controlled delivery using an oil-water solvent evaporation methods by varying PLGA molecular weight and cosurfactant contents. Physicochemical properties and morphology of zaltoprofen-loaded PLGA microspheres were investigated by scanning electron microscope, X-ray diffraction and differential scanning calorimeter. The size of microspheres increased with the molecular weight of PLGA and the content of cosurfactants. The increase of PLGA molecular weight and cosurfactant content decreased the porosity of microspheres, subsequently resulting in the slow drug release. The results demonstrate that the adjustment of PLGA molecular weight and the cosurfactant content allow us to control the drug release profiles of drug-loaded microspheres. |
| 저자 |
유석철, 엄신, 김유진, 유현, 김다영, 조원형, 유일수, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Zaltoprofen; O/W; PLGA microspheres
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| E-Mail |
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