| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Sustaind-release Formulation of Vasartan Tablets Using PVP and HPMC |
| 초록 |
Valsartan, a selective angiotensin II type 1 receptor (AT1R) antagonist, has high bioavailability. However, valsartan can causeas headaches, dizziness and vomiting. It is require to reduce drug initial burst by release of valsartan. Gastrointestinal retentive formulation prepared by HPMC and PVP with mass ratio. As a swollen polymer, HPMC is widely known as hydrophilic carrier for the fabrication of orally controlled drug delivery system. The swelling test was performed to observe the different swelling property with various mass ratio of HPMC and PVP. The in vitro carried out to confirm whether valsartan tablet is soluble in intestinal juice, and controlled experiment was carried out to compare valsartan tablet with conventional drug. This studies showed sustained-release of valsartan tablet by swelling polymer, valsatan as orally pharmaceutical sustained-release formulation. This research was supported by WCU (R31-20029) . |
| 저자 |
오명준, 조원형, 송병주, 유석철, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Valsartan; Swelling polymer; HPMC; Controlled-release
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| E-Mail |
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