| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Characterization and Controlled Release of Solid Dispersed Sibutramine |
| 초록 |
Solid dispersions of poorly water-soluble drug, sibutramine, were prepared with hydrophilic polymer, poly-N-vinylpyrrolidone (PVP), hydroxypropylmethylcellulose (HPMC) and organic acid, citric acid, to improve the solubility of drug. Physicochemical variation and shape of microsphere were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC), Fourier-transform infrared spectroscopy (FT-IR). Microspheres containing additives showed more spherical shape than non additive microspheres. Spray dried sibutramine with citric acid recognized that have amorphous and can be salt. In vitro release behavior of microspheres presented at simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 6.8). Also, PVP and HPMC as additives validated that can be controlled the release of sibutramine. |
| 저자 |
박정수1, 이준희2, 김윤태3, 김명진1, 모종현2, 안식일3, 박종학1, 이해방2, 강길선3
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| 소속 |
1BK-21 Polymer BIN Fusion Research Team, 2Chonbuk National Univ., 3Korea |
| 키워드 |
Sibutramine; Solid Dispersion; Spray Dryer; Controlled Release
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| E-Mail |
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