| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Controlled Release of Granule Tablet Metformin HCl using Hydroxypropylmethylcellulose and Carboxymethylcellulose with Various Viscosity |
| 초록 |
Metformin hydrochloride(MFHCl) is an oral anti-hyperglycemic agent and is highly soluble in water. We prepared the granule tablets of MFHCl in the sustained release dosage form and evaluated their physicochemical properties. MFHCl tablets were prepared with HPMC and CMC with various viscosity and the effects of their viscosity on the drug release was investigated. Differential scanning calorimetry(DSC), x-ray powderdiffractometry(XRD), Fourier transform infrared spectroscopy(FT-IR), swelling test and scanning electron microscopy(SEM) were employed to investigate the physicochemical characterization of the MFHCl in the granule tablets with various viscosity of additives. In vitro release of MFHCl in intestinal fluid(pH 6.8). HPMC and CMC showed various in vitro drug release patterns based on the viscosity. In general, however, the increase of the viscosity of polymer excipients resulted in the increase of swelling and the reduction of in vitro drug release. |
| 저자 |
박현진, 조한수, 홍민성, 홍동현, 오명준, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Metformin HCl; Granule Tablet; HPMC; CMC
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| E-Mail |
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