| 초록 |
Gold nanomaterials that absorb light in near-infrared (NIR) region could be used for simultaneous molecular imaging and photothermal cancer therapy. For effective cancer cell imaging and photothermal therapy, we first prepared gold nanorods (GNRs) with a suitable aspect ratio to have selective absorption in NIR region. Then, pluronic-based, temperature-sensitive nano-carriers were employed as GNR carriers. Gold nanorods (GNRs) were easily loaded into the nano-carriers based on thermo-sensitive properties by incubating simply at 4 °C with high loading capacity and efficiency. GNR-loaded nano-carriers were much more efficient and selective for cancer cell uptake and damaging by laser compared to bare GNRs. Acknowledgement. This research was partially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (MEST) of Korea (R15-2008-006-02002-0). |
