| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Self-assembling and Thermo-sensitive Properties of N-acetylated Glycol Chitosan with Controlled N-acetylation |
| 초록 |
Glycol chitosan (GC) is a water soluble chitosan derivative proposed as a new material for biomedical applications. With the goal of extending the use of GC in drug delivery system, N-acetylated GCs (AC-GCs) with controlled degree of N-acetylation (DA) ranging from 27.55% to 86.42% were successfully synthesized using acetic anhydride in mild conditions. AC-GCs with DA ranging from 27.55% to 59.90% were soluble in DMSO while native GC is practically insoluble in common organic solvents such as DMSO. Biodegradability of GC was improved by N-acetylation, in which faster biodegradation rate was achieved with higher DA. In aqueous media, AC-GC could self-assemble into spherical nanoparticles with a mean diameter of 187.9 nm and unimodal size distribution. Furthermore, AC-GC with DA of 86.42% dissolved in PBS (7 wt%) exhibited thermo-sensitive sol-gel transition at 37 ºС. The AC-GCs with self-assembling and thermosensitive properties could be useful for various biomedical applications. |
| 저자 |
이정정, Thanh Huyen Tran, 허강무
|
| 소속 |
충남대 |
| 키워드 |
Keywords: glycol chitosan; acetylation; self-assembling; sol-gel transition |
| E-Mail |
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