| 초록 |
Self-assembled hyaluronic acid nanoparticles (HA-NPs) have received attention as promising drug carriers for cancer therapy because of their ability to selectively bind to the CD44, which is over-expressed in many cancer cells. However, their preferential accumulation at the liver site and instability of nanoparticles in the bloodstream limited their extended applications. In this study, we attempted to overcome these drawbacks by preparing mineralized PEGylated HA-NPs. These nanoparticles showed high stability in the biological fluids and released the anticancer drug in a sustained manner. Overall, mineralized HA-NPs might have a promising potential as the robust carrier of the anticancer drug. |
