| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Synthesis of poly(ethylene oxide)-block-poly(maleic hydrazide) and its reactivity to dox/fa/mtx/py |
| 초록 |
In this study, poly(ethylene oxide) -block- poly(N-phenylmaleimide) was synthesized by sequential monomer addition technique through living anionic polymerization. Deimidation of poly(ethylene oxide) -block- poly(N-phenylmaleimide) with changing the rection condition such as different ratio of HCl to hydrazine monohydrates and solvent gives various tautomer of poly(ethylene oxide) -block- poly(maleic hydrazide). Conjugation of drug such doxorubicin, methotrexate and fluorescence materials folic acid and 1-pyrenecarboxaldehyde to resulted block copolymer gives acid-sensitive hydrazone bond where conjugated drug is released out through acidic hydrolysis. In this presentation, we report the preliminary results for preparation of the ‘smart’ materials to be used in the drug delivery system. |
| 저자 |
시디크 아부 바카, 김정안, 김윤, 양세라, 김성우, 강호정, 이재열
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| 소속 |
경희대 |
| 키워드 |
PEG; DDS; Anionic polymerization
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| E-Mail |
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