| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Microfluidic Generation of Tissue-specific Beads |
| 초록 |
Microfluidic technique has been applied for microbead generation and the produced microbeads can be utilized in various biomedical fields including 3D cell culture and cell therapy due to their biocompatibility and injectability. Here, we show a tissue bead platform using a flow-focusing microfluidic device to provide tissue-specific microenvironments for enhanced cell culture and functionality. Various tissue-specific extracellular matrices (ECM) were derived from native tissues, which were then used to generate uniform-sized tissue microbeads with a flow-focusing microfluidic device. Tissue-specific microbeads significantly enhanced the viability, maturation, and functionality of the corresponding cell type. This study suggests that tissue-derived matrix combined with microfluidic technique can be used to produce tissue-specific microbeads with increased versatility and efficacy. This research was supported by a grant (19172mfds168) from Ministry of Food and Drug Safety in 2020. |
| 저자 |
이정승1, 노윤호2, 최이선1, 전은제1, 안수환1, 김수연1, 민성진1, 봉기완2, 조승우1
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| 소속 |
1연세대, 2고려대 |
| 키워드 |
microfluidics; microbead; extracellular matrix
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| E-Mail |
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