| 초록 |
Although mesenchymal stem cells (MSCs) and MSC-derived exosomes have been used in tissue regeneration and shown promising therapeutic results, there are still several hurdles to overcome. Here, we introduce exosome-like nanovesicles that can make up for weaknesses of conventional MSCs and MSC derived exosomes. By extruding MSCs repeatedly through filters, nanovesicles were formed and had a significantly smaller size (~120 nm) than that of MSCs (~30 µm) while containing markers of both MSC and exosome. The nanovesicles showed comparable therapeutic performances compared to MSCs and enhanced angiogenesis and neuroprotective ability of endothelial cells and neuronal cells respectively with many growth factors inherited by parent MSCs. |
