| 학회 |
한국화학공학회 |
| 학술대회 |
2012년 가을 (10/24 ~ 10/26, 부산 BEXCO) |
| 권호 |
18권 2호, p.2620 |
| 발표분야 |
환경 |
| 제목 |
Drug loading efficiency and release behavior of chitosan hollow beads: comparison of hydrophobic and hydrophilic drugs |
| 초록 |
In the present study, chitosan hollow beads were successfully fabricated by ionotropic gelation with sodium tripolyphosphate as a counter polyanion. Scanning electron microscopy and paraffin section analysis were used for the structure and morphology studies. The performance of these hollow beads in drug delivery application was studied using two types of drugs including ibuprofen and diltiazem hydrochloride as hydrophobic and hydrophilic model drugs, respectively. Investigation of in vitro drug release behavior was carried out in various pH media. It was observed that the hollow bead exhibited a very clear hollow with distinguished core-shell structure. The results revealed that they were able to encapsulate a larger amount of hydrophobic drug than hydrophilic drug. The release rate of both drugs in simulated intestinal fluid was noticeably higher than that in simulated gastric fluid. |
| 저자 |
Asiah Aibah-Masri1, Thi Phuong Thuy Pham2, 송명희1, 윤영상1
|
| 소속 |
1전북대, 2Department of Bioprocess Engineering |
| 키워드 |
diltiazem hydrochloride; ibuprofen; ionotropic gelation method; oral drug delivery system
|
| E-Mail |
|
| 원문파일 |
초록 보기 |
