| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
대학원생 구두발표 (영어발표, 발표15분) |
| 제목 |
pH-Triggered Silk Fibroin/Alginate Structures Fabricated in Aqueous Two Phase System |
| 초록 |
Recently, considerable effort has been dedicated to search for new aqueous two-phase system (ATPS) polymer pairs in order to further applications. In this paper, a new ATPS system based on silk fibroin (SF) and alginate is introduced. A phase diagram was established to show the critical concentrations for formation of a SF/alginate ATPS. The present system is sensitive to pH stimulus and transformed from an ATPS to a single phasic system as pH increases above ~9.5. Circular dichroism (CD), fluorescence emission spectra, hydrodynamic diameter and zeta potential data together indicate that the SF chains undergo a dramatic extension as pH is increased, which is the reason underlying the pH-triggered phase transition. As feasible applications of this biphasic system, compartmentalized multiplex immunoassay, controlled encapsulation and release, and hierarchical fiber fabrication were demonstrated using the SF/alginate ATPS. |
| 저자 |
박도연1, Jie Cheng2, 신성철3, 이상훈4, 김수현5, 현진호1, Chaoyong James Yang4
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| 소속 |
1한국과학기술(연), 2College of Chemistry and Chemical Engineering, 3Xiamen Univ., 4서울대, 5고려대 |
| 키워드 |
aqueous two phase system; silk fibroin/alginate; compartmentalized multiplex immunoassay; controlled encapsulation and release; biomimicking hierarchical fiber
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| E-Mail |
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