| 초록 |
Toxicity of carbon nanotubes for cancer cells is a paramount issue for future pharmaceutical therapies. Here we report the selective toxicity of carbon nanostructures for brain tumor and nerve cells. Specifically, functionalized carbon nanotubes with serum proteins showed selective viability of brain tissue cells. Using a live cell analysis system, it has been identified that carbon nanotube structures inhibit the proliferation, migration of tumor cells and resulted in same trends with MTT results. Furthermore, viability of fully differentiated neural cells (for cells without proliferation) was not interfered by carbon nanostructures. Overally, this study clearly demonstrated that carbon nanotubes selectively inhibited the proliferation of brain tumor cells, not for differentiated neural cells. In conclusion, this study support the evidence that toxicity of carbon nanotubes, loaded with specific anti-cancer agent, may not interfering adjacent neuronal cells but can inhibiting the tumor growth effectively. |
