| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅱ |
| 제목 |
A Novel Injectable pH–Temperature Sensitive Hydrogel Containing Chitosan–Insulin Electrosprayed Nanosphere Composite for an Insulin Delivery System in Type I Diabetes Treatment |
| 초록 |
Inthis research, a novel insulin composite delivery system was prepared and characterized. Insulin drug was loading in chitoshan nanospheres using electrospraying method, a pH- and temperature-sensitive biodegradable hydrogel, which is an oligomer serine-poly(lactide)-poly(ethylene glycol)-poly(lactide)-oligomer serine (OS-PLA-PEG-PLA-OS) pentablock copolymer was used as a matrix to containning chitosan–insulin electrosprayed nanospheres (CIN). The properties of the OS-PLA-PEG-PLA-OS pentablock copolymer and the chitosan–insulin nanoparticles such as sol-gel transition, degradation in vitro and in vivo were characterized. The results showed that the chitosan–insulin nanospheres uniformly distributed in the matrix had a reinforcing effect on the mechanical properties and prolonged the degradation time of the hydrogel depot under body conditions. In addition, the cytotoxicity experiment results indicate that the composite could be used as a biomaterial for drug delivery system. The composite solutions accommodating different concentrations of the chitosan–insulin nanospheres were subcutaneously injected into induced diabetic BALB/c mice to study the in vivo insulin-release profile. The result showed that insulin concentrations in blood plasma were maintained at a steady-state level. Furthermore, the bio-properties of the insulin were retained and it showed a blood glucose level reducing effect for more than 60 hours after injection to a streptozotocin (STZ)-induced diabetic mouse model. The results suggested that this injectable pH–temperature sensitive hydrogel containing chitosan– insulin electrosprayed nanosphere composites has promising potential applications for type 1 diabetes treatment. |
| 저자 |
Thuy An Trinh1, Thai Minh Duy Le2, Hoang Gia Vinh Ho3, Thi Cam Thach To4, Vu Viet Linh Nguyen1, Dai Phu Huynh2, Doo Sung Lee1
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| 소속 |
1Faculty of Materials Technology, 2Ho Chi Minh Univ. of Technology (HCMUT)/Vietnam National Univ. Ho Chi Minh City, 3School of Chemical Engineering and Theranostic Macromolecules Research Center, 4Sungkyunkwan Univ. |
| 키워드 |
insulin delivery system; pH- and temperature-sensitive hydrogel.
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| E-Mail |
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