| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
On-Demand Self-Assembling Theranostic System Using HyaluronateCucurbituril Conjugate |
| 초록 |
Cucurbituril (CB) is a highly symmetrical macrocyclic molecule showing unique host-guest chemistry with spermine and hexamethylene diamine. In this work, hyaluronate-cucurbit[6]uril (HA-CB[6]) conjugate was synthesized for its drug delivery applications by photoreaction of thiolated HA (HA-SH) with (allyloxy)12CB[6]. We confirmed the successful synthesis of HA-CB[6] conjugate and its self-assembly with spermine derivatives by 1H NMR analysis. The novel HA-CB[6] conjugate was successfully applied for the preparation of on-demand theranostic systems with various functional moieties by host-guest chemistry in a non-covalent manner. In addition, injectable HA hydrogels could be prepared in a few minutes by simple mixing of HA-CB[6] and HA-spermine conjugates. This presentation will give you an overview on the synthesis, characterization, and applications of HA-CB[6] conjugates as novel drug delivery systems. |
| 저자 |
김혜민1, 한세광2, 양정아2, 박경민2, 김기문2
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| 소속 |
1POSTECH, 2포항공과대 |
| 키워드 |
cucurbituril; hyaluronic acid; self-assmebly; theranostic system
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| E-Mail |
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