| 학회 |
한국재료학회 |
| 학술대회 |
2013년 가을 (11/06 ~ 11/08, 제주롯데호텔) |
| 권호 |
19권 2호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
Tissue engineered regeneration of completely transected femur using modified hydroxyapatite porous scaffold |
| 초록 |
The surface modification is considered as one of the important ways of fabricating successful biocompatible materials in bone tissue engineering. In this study, surface of porous Hydroxyapatite (HAp) scaffolds have been modified by collagen treatment and rhBMP-2 conjugation for bone regeneration. HAp materials have received considerable attention as suitable bioceramics for the manufacture of osseous implants due to their similarity to bone mineral in terms of chemical composition. The in vitro studies were investigated to evaluate the effective of the modified surface compared to unmodified HAp surface. The rabbit model was prepared by complete removal of a 5-mm length of femur. The aim of the current study was to advance a treatment strategy for regeneration of completely transaction model, a finding that could have significant implantation for clinical application using three-dimension scaffolds HAp and HAp with collagen and BMP-2 surface modification. |
| 저자 |
Nguyen Thuy Ba Linh1, Dong-Woo Jang2, Shin Woo Kim3, Kim Hyeong Seok4, Andrew R. Padalhin5, Young Ki Min3, Byong-Taek Lee4
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| 소속 |
1Department of Regenerative Medicine, 2Institute of Tissue Regeneration, 3College of Medicine, 4Soonchunhyang Univ., 5Department of Regenerative medicine |
| 키워드 |
Hydroxyapatite; Surface modification; Collagen treatment; BMP-2 coating; bone tissue engineering
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| E-Mail |
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