초록 |
In the present study, we pointed to the influence of racemate mandelic acid excess on the solubility of the two diastereomeric salts formed by mandelic acid and the resoving agent L-phenylalanine. The results has shown that the solubility of L-mandelic.L-phenylalanine was reduced in the presence of D-mandelic.L-phenylalanine. In addition, in the little excess of mandelic acid, the solubility of L-mandelic.L-phenylalanine was inversely proportional to the increase of mnadelic acid. At a high excess, however, mandelic acid make L-mandelic.L-phenylalanine dissolve better. As a result, the optical purity improvement can be obtain certainly. |