| 학회 |
한국화학공학회 |
| 학술대회 |
2011년 봄 (04/27 ~ 04/29, 창원컨벤션센터) |
| 권호 |
17권 1호, p.1083 |
| 발표분야 |
특별 심포지엄 |
| 제목 |
RNA synthetic biology for cellular reprogramming |
| 초록 |
Synthetic biology has emerged as a promising research area that enables researchers to simplify complicated biological systems into manageable pieces and to redesign brandnew biological circuits by assembling the simplified biological modules recruited from different living organisms. Several approaches have been investigated to provide logical connectivity between well-defined binding events among relevant biomolecules and the way how the biomolecualr interactions lead to programmable circuit behaviors. These include engineering of biological circuits like gene regulatory systems, metabolic fluxes and signal transduction pathways. Riboregulatory genetic control has been attracting increasing attention as recent research reveals that noncoding RNA elements and ligand-binding regulatory mRNAs play pivotal roles in control over celluar gene expression through several mechanisms including RNA interference and riboswitching. We are interested in constructing synthetic biological circuits by exploiting the riboregulatory elements, because it promises great potential to biomedical applications and research tools for simplifying biological systems into reconstitutive modules. Here we present a novel synthetic riboregulatory system that is switchable by small chemicals. |
| 저자 |
신종식 |
| 소속 |
연세대 |
| 키워드 |
합성생물학; RNA; 리보스위치; 유전자 발현조절
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| E-Mail |
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| 원문파일 |
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