| 초록 |
Hyaluronic acid (HA) has currently several therapeutic applications. HA has the relevant advantage of biocompatible, biodegradability, and specific targeting on cancer cell. This research focused on core-shell formation with silica particle and dopamine modified HA. The process was performed on different pH conditions in order to investigate core-shell formation. It was found that the redox state of dopamine is a key factor to form core-shell particles. Substituted ratio of dopamine modified HA was determined by using 1H-NMR. The core-shell particles` size and morphology were measured by DLS, AFM. The chemical compositions of core-shell particles formed in different pH were analyzed by FT-IR, XPS. To suggest definite images of core-shell structures, the core-shell formation was observed by SEM, Bio-TEM. |
