| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
International Symposium on Advanced Biopolymers (의료용 고분자 부문위원회, 영어발표) |
| 제목 |
Design of Multifunctional Degradable Polymeric Nanosystems for Active Tumor-Targeting Drug Delivery |
| 초록 |
The clinical success of many chemotherapeutics and biotherapeutics intimately depends on the development of non-toxic and efficient tumor-targeting nano-carrier systems. In the past years, we have designed and developed various types of stimuli-sensitive degradable polymeric nano-vehicles for tumor-targeting drug and protein delivery, which include (i) bio-responsive, in particular reduction- and pH-responsive, degradable micelles and polymersomes for efficient loading and targeted intracellular release of anti-cancer drugs and proteins; (ii) robust and stimuli-sensitive micelles and polymersomes to simultaneously resolve the in vivo stability and drug release dilemma; and (iii) acid-sensitive prodrugs, prodrug nanoparticles, and prodrug nanogels that are sufficiently stable during circulation but activable inside the target tumor cells in response to a low pH in the endo/lysosomal compartments. |
| 저자 |
Yinan Zhong1, Ru Cheng2, Chao Deng3, Fenghua Meng4, Jian Zhang5, Zhiyuan Zhong1
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| 소속 |
1Biomedical Polymers Laboratory, 2and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, 3College of Chemistry, 4Chemical Engineering and Materials Science, 5Soochow Univ. |
| 키워드 |
multifunctional; drug delivery; nanosystem
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| E-Mail |
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