| 초록 |
Agarose-based hydrogels are used for three-dimensional culture of human and animal cells and are widely used in drug delivery systems. However, the high gelation temperature and high stiffness of agarose limits its applicability for various applications. In this study, β-Cyclodextrin (βCD) was introduced into agarose to control the mechanical properties of agarose and to develop a hydrogel with low gelation temperature. This synthetic CD-agarose (CFA) has a lower gelation temperature than conventional agarose, allowing for effective loading of the drug at room temperature. CFA gels could be used for complete release of bovine serum albumin and sustained release through inclusion complexation of βCD against doxorubicin. CFA is not cytotoxic and could be used in a variety of drug delivery systems. |
