| 초록 |
Zwitterionic polymer dot(Z-PD) coated substrates were designed to monitor and manipulate cell adhesion and detachment because of their high sensitivity over a wide range of pH conditions. At neutral pH, Z-PD-coated wireless sensors exhibited π–π stacking involving aromatic rings with hydrophobic interactions, thereby promoting cell proliferation. Z-PD-coated substrates triggered by acidic and basic conditions promoted cell detachment, which induced an increase in the resistance compared with Z-PD substrates at pH6.8. Therefore, a wireless biosensor was designed which showed excellent pH responsiveness by facilitating cell proliferation and detachment. Z-PD biosensors demonstrated a more favorable approach for monitoring cell–surface interactions than conventional optically based methods. This work supported by Korea Institute for Advancement of Technology (KIAT) grant funded by the Korea Government (MOTIE) (P00008500, The Competency Development Program for Industry Specialist). |
