| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Bioactive polyaniline nanoparticles as nano-intraobserver for detection of reactive oxygen species in vitro |
| 초록 |
Recently, the interest in reactive oxygen species (ROS) originally revolved around the pathology associated with the deleterious effects such as inflammation and signal transduction: the necessary evil caused by the leakage from the electron transport chain in mitochondria. Therefore, intraobserver for detecting ROS is critical to both understanding the etiology of the disease and optimizing therapeutic interventions. Herein, we report the bioactive polyaniline nanoparticles as nano-intraobserver for detection of ROS. Polyaniline, a class of conducting polymers, renders the transition from an emeraldine salt (ES) state to an emeraldine base (EB) state exhibiting optical change under the excessive amount of ROS. As nano-intraobserver, we synthesized mPEG coated Cy7 (as a quencher) conjugated polyaniline nanoparticles that can accurately recognize intra-cellular ROS level by generation of fluorescence resonance energy transfer (FRET) signal due to the transition from ES to EB in vitro. |
| 저자 |
임종우, 최지혜, 김지혜, 김현욱, 윤다연, 서진석, 허용민, 함승주
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| 소속 |
연세대 |
| 키워드 |
Polyaniline; Conducting Polymer; Reactive Oxygen Species; ROS; Fluorescence Resonance Energy Transfer; FRET
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| E-Mail |
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