| 학회 |
한국재료학회 |
| 학술대회 |
2017년 가을 (11/15 ~ 11/17, 경주 현대호텔) |
| 권호 |
23권 2호 |
| 발표분야 |
B. 나노화학/바이오 분과 |
| 제목 |
A hybrid composite system of BCP granules loaded with hyaluronic acid-gelatin hydrogel for bone regeneration |
| 초록 |
An ideal bone substitute should be made of biocompatible materials that mimic the structure, characteristics and functions of natural bone. In the present study, we incorporated hyaluronic acid-gelatin hydrogel to micro-channeled biphasic calcium phosphate (BCP) granules as a carrier to improve cell attachment and proliferation through highly interconnected porous structure. This hybrid system is composed of ceramic BCP granules measuring 1mm in diameter with 7 holes and hyaluronic acid-gelatin (HG) hydrogel. The resulting scaffold had a porosity of 56% with a suitable pore sizes. The mechanical strength of BCP granule increased after loading HG from 4.26 ± 0.43 to 6.57 ± 0.25 MPa which is highly recommended for cancellous bone substitution. In vitro cytocompatibility studies were observed by preosteoblasts (MC3T3-E1) cell line and the result revealed that BCP/HG significantly increased cell growth and proliferation compared to BCP granules. Analysis of micro-CT data and stained tissue sections from the implanted samples showed better bone formation in the scaffold 1 and 2 months post-implantation. Histological section confirmed the formation of dense collagenous tissue and new bone in BCP/HG scaffolds at 2 months. Our study demonstrated that such hybrid BCP/HG scaffold is a promising system for bone regeneration. |
| 저자 |
Omar, 이병택
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| 소속 |
순천향대 |
| 키워드 |
Hyaluronic acid; gelatin; biphasic calcium phosphate; composite; bone substitute
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| E-Mail |
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