| 초록 |
Aptides, a novel class of high-affinity peptides, are designed to possess a “tweezers-like” structure comprising a unique structure-stabilizing scaffolding region and two high-affinity target-binding components. We have produced aptides with nanomolar-range binding affinities for several targets using phage display selection, demonstrating the utility of this technology. Indeed, peptides with high target affinity isolated from aptide libraries have offered the potential for use as diagnostic or drug candidates. An aptide targeting the tumor biomarker fibronectin extradomain B (EDB) showed remarkable in vivo accumulation at the tumor site. Thus we have utilized the anti-EDB aptide for various biomedical applications, including targeted drug delivery, cancer imaging by MRI, and targeted protein therapeutics. In this lecture, bio-inspired design, characterization, and a couple of biomedical applications of aptides will be presented. |
