| 초록 |
Recently, sonodynamic therapy(SDT) using sonosenitizers encapsulating nanoparticles has been intensively investigated, due to the limitation of photodynamic therapy(PDT) of the light penetration depth. However, the hypoxic condition of cancer tissue limits the effectiveness of SDT. In this study, we loaded decafluoropentane (DFP) with high oxygen carrying capability in the core of a phospholipid based nanodroplet. Also, for SDT, verteporfin was loaded in the nanodroplets(VP-NDs). When the VP-NDs are delivered to the cancer tissue, high intensity focused ultrasound (HIFU) is irradiated for the evaporation of the DFP and the cavitation of VP-NDs, while temporarily generating heat and releasing excess oxygen to overcome hypoxic condition. The HIFU-activated VP-NDs generated sufficient amounts of ROS and demonstrated improved sonodynamic therapy efficacy. In conclusion, VP-NDs showed sufficient potential in cancer therapy by overcoming the hypoxic tumor and the limitations of PDT. |
