| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
신진연구자 특별 심포지움 (영어발표) |
| 제목 |
Directed in vitro myogenesis of human embryonic stem cells and their in vivo delivery using biomimetic materials |
| 초록 |
The ability of human embryonic stem cells (hESCs) to differentiate into skeletal muscle cells and contribute to tissue regeneration has shown great promise to treat debilitating skeletal muscle diseases. However, efficient differentiation of hESCs into skeletal muscle cells and their in vivo survival and function within host tissues upon transplantation remains a daunting task. To improve the in vivo functions of these transplanted cells, we developed a biomimetic polymer-based cell delivery vehicle can mimic the structural and functional properties of native proteoglycans. The results described in this study provide a proof-of-principle that hESC-derived myogenic progenitors have in vivo engraftment potential and employing biomimetic materials as a delivery vehicle could considerably promote in vivo survival and function of the transplanted cells. |
| 저자 |
황용성 |
| 소속 |
순천향대 |
| 키워드 |
myogenesis; biomimetic materials; human embryonic stem cells
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| E-Mail |
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