| 학회 | 한국화학공학회 |
| 학술대회 | 2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 | 22권 2호, p.2581 |
| 발표분야 | KIChE-SCEJ joint symposium(특별 심포지엄) |
| 제목 | In vitro tissue models using microscale technologies for drug development |
| 초록 | In drug development process, a lot of drug candidates are failed during clinical test because of low efficacy, adverse effects, etc. Low reliability of preclinical tests using animal models or cultured cells is seen as one of the reasons of this failure. Thus, new methods and systems of preclinical tests which more accurately represent human physiological response is required. We have developed in vitro tissue models by using microscale technologies aiming to use as new preclinical tests. In this presentation, we will introduce our in vitro tissue models as follows. 1. In vitro skeletal muscle tissue models. Contraction is one of the key functional features of skeletal muscle cells/tissues. We have developed several systems to quantify their contraction by using microscale technologies. 2. In vitro cancer models. Metastasis leads to low survival rate of patients. We developed 3-dimensional in vitro co-culture models of cancer cells and vascular endothelial cells by using our original magnetic cell patterning method. This model might be used for developing anti-metastatic drugs. |
| 저자 | Kazunori Shimizu1, Hiroyuki Honda2 |
| 소속 | 1Department of Biotechnology, 2Graduate School of Engineering |
| 키워드 | In vitro tissue model |
| 원문파일 | 초록 보기 |
