| 초록 |
Growing evidence indicates that both the chemical and architectural properties of scaffolds have tremendous influence on the in vitro and in vivo activities of various types of cells. Electrospinning has emerged as a potent tool in tissue engineering since it can easily produce fibrous structures which present large surface area for chemical modification and cell binding. In addition, modulation of spinning set-up can generate fibers with topologically controlled structure, which have become an interesting platform in tissue engineering since they can structurally mimic some of the native tissue organization such as skeletal muscle, endothelial lumen, or cancellous bone. In this presentation, the effect of these well-defined geometries derived from nanofibers on in vitro cell responses and in vivo tissue formation will be discussed with several examples. |
