| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.59 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Water-Soluble mPEG-PLGA Copolymer as Surfactant in Controlled Drug Delivery : Polymerization and Characterization and Preparation of Drug Loaded Nanoparticles |
| 초록 | Drug carrier formed by a poly(ethylene glycole) (PEG) corona, sterically protects the carrier, avoids their interaction with plasma proteins and phagocytic cells, and thus significantly increase the circulatory blood half-lives of these carrier. Poly(D,L-lactide-co-glycolide) (PLGA) is biodegradable and biocompatible. Non-biodegradable surfactant , such as poly(vinyl alcohol) (PVA) , remains in the final composition of the particles. Residual PVA amounts as high as 52%. BiodegradableSurfactant would replace the commonly non-biodegradable surfactant. In this study, PEG-PLGA di/block copolymer with different HLB was synthesized by ring-opening polymerization. CMC was determined by surface-tension meter. Drug loaded nanoparticles were prepared by emulsification-diffusion method. The size and zeta potentialof the nanoparticles were determined using photo correlation spectroscopy (PCS) and microelectrophoresis. |
| 저자 | 한승훈, 손서연, 김중현 |
| 소속 | 연세대 |
| 키워드 | nanoparticle; surfactant; biodegradable |
