| 초록 |
Biodegradable porous polymer scaffolds have been extensively used for temporal templates for tissue regeneration and drug carrier for sustained local delivery of various proteins and growth factors. Previously, we reported that macroporous biodegradable poly(lactic-co-glycolic acid) (PLGA) scaffolds could be fabricated based on a salt leaching/gas foaming method using a mixture of effervescent salts. The present study aims at the fabrication of biodegradable porous scaffolds for local sustained drug delivery of angiogenic growth factors such as basic FGF and VEGF. Heparin was immobilized onto the surface of PLGA scaffolds. Heparin was immobilized onto the scaffolds by the formation of covalent bond between carboxylic groups of heparin and surface-exposed amine groups on the PLGA blend scaffolds. Release rates of basic FGF from the heparin-immobilized PLGA scaffolds were comparatively examined. As a result, the angiogenic growth factor, basic FGF, could be incorporated onto heparin immobilized biodegradable polymeric scaffolds by a gas-foaming/salt-leaching method. Sustained release of bFGF from the scaffolds could be achieved over 20 days. |
