| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.70 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Effect of bone marrow-derived stromal cells on tissue engineered spinal cord |
| 초록 | Several studies have been made on spinal cord regeneration by bone marrow-derived stromal cells (BMSCs). Transplantation of BMSCs has been regarded as a potential approach for promoting nerve regeneration. In this study, we made biodegradable implant using polyglycolide (PGA) nonwoven, Pluronic F127, and small intestinal submucosa (SIS) for tissue engineered spinal cord. BMSCs were harvested from the femur of adult female Fischer rat. Fischer rat received an implant consisting of the BMSCs in the gap (T8-T9; 5mm) created by the spinal cord resection. For histological evaluation, the implants were removed after 4~8 weeks. It was observed that the implant with BMSCs in neuroinduction are stronger than without BMSCs and blank. In conclusion, it seems that biodegradable implants act on useful guidance for spinal cord regeneration of tissue engineering. Acknowledgement: This work was supported by KMOICE (N11-A08-1402-05-1-3). |
| 저자 | 박기숙1, 장지욱2, 최진산3, 이상진3, 이봉2, 이일우4, 이혜경4, 김문석3, 조선행3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2부경대, 3한국화학(연), 4가톨릭의과대 |
| 키워드 | spinal cord regeneration; BMSCs |
