| 초록 |
PEGylation, the covalent conjugation of poly(etyleneglycol) (PEG) to clinical compounds, is a conventional method for long-term delivery of drug-encapsulated nanocarriers and therapeutic proteins. However, the covalent PEGylation accompanies the uncontrollable chemical reactions, resulting in a loss of their biological activity. Herein, we found a reversible protein modification method, termed TANNylation, using a plant-originated molecular glue, tannic acid (TA). We demonstrated the stoichiometric chemistry for the stable formation of TANNylated proteins via hydrogen bonds. Furthermore, TANNylated proteins was accumulated to the heart inner wall by the intermolecular interaction between TA and the extracellular matrix proteins, showing controlled release characteristics into blood stream. Our findlings indicate that TANNylation might be a reversible protein-delivery strategy for targeting to the heart as well as slowly releasing into blood. |
