| 초록 |
Cortisol well-known as a stress hormone level should be regulated and measured condignly. In this research, cortisol biosensing platform was fabricated. Electrode of the biosensor was manufactured by fabrication metallic MXene which shows fascinating electrical conductivity and biocompatibility. PEDOT:PSS was brought to make adhesion between MXene and substrate through electrostatic interaction and van der waals force. Modification of functional groups should be preceded by immobilization of antibody. Hydroxyl group, one of functional group of MXene, was modified with oxalic acid one of dicarboxylic acid. Carboxyl groups on modified MXene can be reacted with amino groups emerging amide bonding through EDC chemistry. Finally, BSA was introduced to passivate non-specific binding. Among a bunch of methods in sensing system, EIS which indicates outstanding performance in selectivity and sensitivity. It is expected that MXene could be employed as a pleasant platform for biosensors. |
