| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Cell-adhesive nanopost height controls pre-osteoblast phenotype |
| 초록 |
A biomimetic approach to generate nano-patterned surface is critical for scaffold design in tissue engineering. We hypothesized that the height of cell-adhesive nanoposts on a scaffold surface could be a key factor to regulate the proliferation and differentiation of pre-osteoblasts. Nano-patterned surfaces were fabricated using self-assembly of polystyrene-b-poly(ethylene oxide)/dodecylbenzensulfonic acid (PS-b-PEO/DBSA) complex systems. PS nanopost heights were controlled through the film thickness and were ranged from 11 to 43 nm. Adhesion and growth of MC3T3-E1 cells were greatly influenced by varying PS nanopost heights. Differentiation of the cells was also tested under osteogenic conditions for 14 days. Expression levels of RUNX2 and osteocalcin, a typical marker of osteogenic differentiation, were also substantially affected by PS nanopost heights. |
| 저자 |
정은주1, 이진욱2, 곽영제3, 김승현2, 이근용1
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| 소속 |
1한양대, 2인하대, 3숭실대 |
| 키워드 |
nanotopography |
| E-Mail |
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