| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
Effect of different hemisphere shape pore size and depth on cellular behavior |
| 초록 |
Surface morphology of cell culture substrate is well known as an important factor for determining cellular behaviors. There have been many attempts to figure out the influences of surface morphologies. However, there was no research studying the influence of different pore size and depth on the cellular behavior. In this study, different size and depth pores are fabricated on PDMS surface by leaching out polystyrene particles fabricated by SPG membrane. PDMS surface after polystyrene particles are leached out has uniform crater shape pores. We controlled the pore size on PDMS substrate by using different size polystyrene particles. Depth of pore also can be controlled by pre-curing method. We studied the cellular behavior by culturing 3T3 on our substrate. The result demonstrates that smaller and deeper pore inhibits cell adhesion. Our substrate can be further used for studying the cellular behavior of different cell types and the differentiation of stem cells. |
| 저자 |
유병용, 민지홍, 김민수, 국윤민, 정윤아, 이재상, 노소영, 고원건
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| 소속 |
연세대 |
| 키워드 |
Biomaterial; PDMS; Surface modification
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| E-Mail |
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