| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Mineralized Robust Nanoparticles for Enhanced Intracellular Nitric Oxide Delivery |
| 초록 |
Nitric oxide (NO) has attracted a growing interest because it can express the apoptotic activity for various cancers. At a high concentration level of NO, it can inhibit tumor growth. Herein, we selected S-nitrosoglutathione (GSNO) as an NO precursor. GSNO-loaded calcium carbonate-mineralized nanoparticles (GSNO-MNPs) were prepared by sequentially adding the aqueous solutions of GSNO and CO32- ions to an aqueous mixture of the anionic block copolymers (PEG-Poly(L-aspartic acid)) and Ca2+ ions. The stability of GSNO shielded within the crystalline CaCO3 core was greatly enhanced. The GSNO-MNPs triggered NO release at endosomal pH and an intracellular ascorbic acid level. In vitro cell experiments demonstrated that NO release by the GSNO-MNPs efficiently improved therapeutic activity of doxorubicin. |
| 저자 |
이홍재, 김다은, 이상천
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| 소속 |
경희대 |
| 키워드 |
Nitric Oxide Delivery; S-nitrosoglutathione; Mineralized Nanoparticles
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| E-Mail |
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