| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | A Novel Polycaprolactone/Hydroxyapatite Scaffold for Bone Tissue Engineering |
| 초록 | The development of biocompatible materials which can be processed into three-dimensional scaffolds and design of appropriate configuration to enable the cellular infiltration and proliferation are one of the major issues in the tissue engineering. Polycaprolactone(PCL) is a well known hydrophobic biodegradable polymer and it is non-toxic aliphatic polyester with biocompatibility. The PCL has a potential as one of promising bone substitute materials because of its slow degradation properties and good biocompatibility. Hydroxyapatite(HA) is main component of bones in mammals. HA has sufficiently good mechanical properties with superior biocompatibility to be utilized as bone implant materials. In this study, novel PCL/HA scaffolds were prepared to increase mechanical properties and degradation of PCL/HA ones for bone tissue engineering. First of all, PCL macromer was synthesized through the reaction of PCL diol with acryloyl chloride[1]. PCL macromer was confirmed using Fourier transform infrared and nuclear magnetic resonance spectrometer. Three-dimentional PCL networks were obtained by photopolymerization of PCL macromer. Thermal, mechanical, and morphological characteristics as well as degradability and biocompatibility of the PCL/HA scaffolds prepared by gas-foamong method were investigated. The PCL/HA scaffolds degradation studies were performed in phosphate buffered saline. The porosity of the PCL/HA scaffolds was checked by scanning electron microscope. Proliferation of MG63 osteoblast cell in the PCL/HA scaffolds were checked in vitro. The compressive modulus of PCL scaffold obtained from PCL diacrylate was higher than that of PCL itself. PCL network showed faster degradation behavior than PCL itself due to incorporation of many ester groups into PCL network and the lower crystallinity than PCL itself. Human osteoblast cell culture showed that the scaffolds were biocompatible and it can be expected to use as scaffold for bone tissue engineering. Reference 1. Kwon H.Y., Yoo M.K., Park I.K., Kim T.H., Lee H.C., Lee H.S., Oh J.S., Akaike T.,Cho C.S. Biomaterials, 24, 801-808(2003). |
| 저자 | 송호현, 유미경, 조종수 |
| 소속 | 서울대 |
| 키워드 | polycaprolactone; hydroxyapatite; scaffold; tissue engineering; osteoblast |
