| 학회 |
한국재료학회 |
| 학술대회 |
2019년 봄 (05/15 ~ 05/17, 평창 알펜시아 리조트) |
| 권호 |
25권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Fabrication and Characterization Decellularized Blood Vessels Reinforced with Electrospun Fibers as Artificial Bypass Conduits |
| 초록 |
Although several implantable materials have been developed for bypass procedures, continuous improvements in terms of long-term biocompatibility and patency are still required. This study focuses on the development of an implantable bypass conduit by combining tissue decellularization and polymer electrospinning. Decellularization was used to remove cellular components from extracted blood vessels to render a highly biocompatible scaffold composed of extracellular matrix (ECM) from the native blood vessel. These decellularized blood vessels have been known to have better biocompatibility but have been shown to have significantly compromised mechanical strength. Electrospinning has been proven to be a suitable fabrication method for sheet and tube type scaffolds for tissue regeneration. An electrospinning method was developed and optimized to reinforce decellularized blood vessels with electrospun fibers. The study aims to incorporate electrospun polymer fibers throughout the decellularized scaffold. The resulting reinforced tubular scaffold was characterized through microscopic observation, tensile strength testing, and contact angle measurement. Biocompatibility of the resulting sample was observed through testing cell adhesion, viability, proliferation, and hemocompatibility testing. |
| 저자 |
John Patrick Cuenca1, Byong Taek Lee2
|
| 소속 |
1Department of Regenerative Medicine, 2College of Medicine |
| 키워드 |
Decellularization; Electrospinning; Blood Vessels
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| E-Mail |
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