| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Biocompatibility Evaluation of Three Dimensional CMC scaffold for Rat Bone Marrow Mesenchymal Stem cell |
| 초록 |
Various naturally and synthetic derived biomaterials have been successfully used for three dimensional scaffolds. Sodium carboxymethylcellulose (CMC) can be widely used for a scaffold. CMC has carboxylic acid as a polyanion group. The anions of the CMC may act as a point of electrostatic interactions with cations. A polycation, poly(ethyleneimine) (PEI) is one of the most extensively used biomaterials. We prepared CMC gel via electrostatic interactions of an amine group in PEI and a carboxylic acid group in CMC. And we performed seeding of rat BMSCs (rBMSCs) in CMC gel scaffold and examined host tissue responses to the CMC gel scaffold by immunohistochemical staining. As a results, injection of CMC gel alone induced macrophage accumulation in the host tissue, whereas injection of CMC gel containing rBMSCs was associated with less macrophage accumulation. Thus, rBMSC containing CMC gel scaffolds show good biocompatibility and guarantee adequate engraftment within the host tissue. |
| 저자 |
강윤미1, 김이슬1, 이주영2, 김경해1, 강꽃님3, 김재호1, 민병현1, 이해방2, 이봉3, 김문석1
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| 소속 |
1아주대, 2한국화학(연), 3부경대 |
| 키워드 |
CMC; PEI; Scaffold; Biomaterial
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| E-Mail |
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