| 초록 |
Articular cartilage has little capability of self-repair once damaged by traumatic injuries or osteoarthritic diseases. Based on the concept of tissue engineering, many studies seek a way of making a hyaline-like cartilage tissue using polymeric scaffolds, chondrocytes, adult stem cells, and growth factors. Each component has its own significance but also poses its own limitation. While fascinating scaffold materials and designs, i.e., nanofiber, have been developed, there are still challenges to be addressed, including cell attachment, distribution, and biocompatibility. Redifferentiation of dedifferentiated chondrocyte is another issue, along with the ways of inducing chondrogenic differentiation of stem cells. Effective delivery of growth factors and proper mechanical stimulation is also of importance. These topics are closely interconnected each other, sharing the ultimate goal of building a high quality tissue-engineered cartilage. |
