| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Cartilage tissue engineering using 3-Dimensional and Dynamic Environments |
| 초록 |
In our previous studies, it was confirmed that mechanical stimuli enhanced the development of engineered cartilage tissues in elastic mechano-active PLCL scaffolds. It is known that the three-dimensional spatial organization of cells and extracellular matrix is crucial to functional cartilage formation. The purpose of this study is to form substantial tissue engineered cartilage with hybridization of hydrogels and PLCL scaffolds in dynamic environment by mechanical stimulation. The BMSCs were seeded onto scaffolds suspended in a solution of hydrogels and the continuous compressive deformation was applied. From the results, the proper periodic application of dynamic compression and 3-dimensional environments of the hybrid scaffolds of fibrin gels and elastic PLCL scaffolds can encourage BMSCs to differentiate to chondrocytes, maintain their phenotypes and enhance GAGs production and consequently, improve the quality of cartilaginous tissue formed in vitro and in vivo. |
| 저자 |
정영미1, 김상희1, 김수현1, 김상헌1, 김영하2, 민병구3
|
| 소속 |
1한국과학기술(연), 2광주과학기술(연), 3서울대 |
| 키워드 |
hydrogel; mechanical stimulation; bone marrow stromal cells; cartilage tissue engineering
|
| E-Mail |
|
