| 초록 |
Controlled drug delivery system is important for the realization of therapeutic efficacy. Among the various systems, using thermosensitive polymers have drawn much attention because this stimulus occur in the body and can be given from outside, which makes it easier to control. Here, we introduce Poly(N-vinyl caprolactam) (PVCL) microparticles for controlled drug release. Unlike Poly(N-isopropyl acrylamide) (PNIPAm), PVCL has good biocompatibility to be utilized in the body. PVCL microparticles were fabricated via Stop Flow Lithography (SFL) technique. We confirmed that polymer network in particles are broken above certain temperature known as lower critical solution temperature (LCST). After adjusting the LCST to body temperature by adding poly ethylene glycol 700 diacrylate (PEG 700 DA) as a hydrophilic component, we conducted the drug release test using Doxorubicin as a model drug and revealed that the releasing rates were significantly higher at above LCST than below LCST. |
