| 초록 |
NanoBiotechnology holds enormous promise in the diagnosis and treatment of many human diseases with unmet medical needs, such as cancer. To this end, the overarching goal of my research is to develop novel nanotherapeutic platforms for use in targeted/controlled drug delivery and is also to design functional biomaterials for various applications in cancer immunotherapy. This includes developing synthetic nanovectors effectively overcoming multidrug resistance and eradicating cancer stem cells that ultimately causes cancer recurrence. My research is also aimed at engineering virus-based nanoparticles for targeted gene therapy by interlacing crucial properties of viral and non-viral vectors. In addition, inefficient delivery of drug/gene to target cells in vivo environment always remains obstacles for the clinical translation of therapeutic vectors. To overcome such challenges, I developed a novel strategy for in vivo modulation of target cells by using a biomaterial scaffold to create a physical microenvironment where target cells can be recruited and proliferated, demonstrating that this approach could remarkably enhance the delivery efficacy of drug/gene to target cells in vivo. |
